# İkinci Bir Şans: Geleceği İnşa Etmek | özgür dandin | TEDxKirmiziCizgiHighSchool

Source: https://www.youtube.com/watch?v=g5C9uEAVcwY
Recap page: https://rapidrecap.app/video/g5C9uEAVcwY
Generated: 2026-02-18T18:04:25.351+00:00

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## Quick Overview

Dr. Özgür Dandin presents his cutting-edge research on regenerative medicine, particularly focusing on xenotransplantation (using genetically modified pig organs for human transplant) and the potential of using amniotic fluid as a superior organ preservation solution, citing successful preclinical trials with pig livers that functioned after being preserved in this fluid.

**Key Points:**
- Dr. Dandin was born in Giresun's Görele district in 1978 and completed his medical education at Gülhane Military Medical Academy, later serving as Chief Physician at a NATO post.
- He pursued research in organ transplantation, xenotransplantation, regenerative medicine, and biomedical technologies, including work at the University of Tennessee and as the owner of Aeternos Sol, a biotech company.
- He highlights the historical human quest for immortality, citing Gilgamesh and Egyptian myths, and contrasts this with modern efforts like genetic engineering and regenerative medicine.
- A major focus is on using genetically modified pig organs for human transplants, referencing a 2022 study in 'Stem Cell Research and Therapy' that showed promise for chronic liver disease.
- His research involves developing organ perfusion systems and testing amniotic fluid as an organ preservation solution, showing that pig livers preserved in this fluid maintained function for up to 17 days.
- The speaker mentions preliminary positive results showing reduced cell death (apoptosis) in organs preserved with amniotic fluid compared to standard solutions.
- Future projects include developing portable organ perfusion devices (one receiving a 4 million TL TÜSEB grant) and advancing 'in vivo' organ regeneration.

![Screenshot at 07:06: A slide illustrating the experimental setup for organ preservation, showing a machine perfusion system, a 'Normal' pig liver, and a liver that has undergone 'Hücresizleştirme' \(decellularization\), demonstrating the complex technology used in his research.](https://ss.rapidrecap.app/screens/g5C9uEAVcwY/00-07-06.jpg)

**Context:** The presentation is delivered by Doç. Dr. Özgür Dandin at a TEDx event, focusing on his medical and scientific research aimed at overcoming organ shortage, primarily through xenotransplantation and advanced organ preservation techniques. Dandin frames his work within the historical human desire for longevity and immortality, transitioning from ancient myths to modern scientific solutions like regenerative medicine and bioengineering.

## Detailed Analysis

Dr. Özgür Dandin begins by thanking his team and acknowledging his background, including graduating from Gülhane Military Medical Academy and working in various locations across Turkey before establishing his biotech company, Aeternos Sol. He connects his work to the ancient human obsession with immortality, referencing Gilgamesh and Egyptian practices, and argues that modern medicine, through genetic engineering and regenerative medicine, is actively pursuing this goal. A significant portion of his talk focuses on xenotransplantation, specifically citing a 2022 study showing that genetically modified pig organs could be a viable alternative for chronic liver disease patients. He details his own research, including developing organ perfusion systems and testing amniotic fluid as a superior preservation medium, noting that pig livers preserved in this fluid maintained function for up to 17 days. Histological analysis showed reduced cell death (apoptosis) in these preserved organs compared to control groups, which he describes as 'sevindirici' (heartening) results. Dandin also mentions developing a portable organ perfusion device, which secured a 4 million TL TÜSEB grant, and discusses the ethical consideration of why we preserve organs for animals but not for humans. He concludes by outlining future projects, including further organ regeneration and developing wearable technology to monitor tissue oxygen saturation.

### Personal and Professional Background

- Born in Giresun in 1978
- Graduated from Gülhane Military Medical Academy
- Worked in Istanbul, Ankara, Trabzon, Bursa, and served as Chief Physician in NATO
- Owns biotech company Aeternos Sol

### The Quest for Immortality

- Explored through ancient myths (Gilgamesh, Egyptian mummification)
- Modern approaches include Genetic Engineering and Regenerative Medicine

### Xenotransplantation Research

- Referenced a 2022 study on genetically modified pig organs for chronic liver disease
- Conducted experiments preserving pig livers in amniotic fluid for up to 17 days

### Organ Preservation Fluid

- Amniotic fluid contains growth factors and anti-inflammatory molecules, making it superior to standard solutions for keeping organs viable outside the body

### Experimental Results

- Histological analysis showed reduced apoptosis (cell death) in organs preserved with amniotic fluid compared to controls, indicating positive outcomes.

### Future Projects

- Developing portable organ perfusion machines (TÜSEB grant secured)
- Tissue engineering for organ regeneration (e.g., liver, pancreas)
- Wearable technology for monitoring tissue oxygen saturation (patent stage)

### Acknowledgements

- Thanked his family for their patience and the entire team for their dedicated work.

![Screenshot at 00:06: The speaker, Doç. Dr. Özgür Dandin, walking onto the stage at TEDxKırmızıÇizgi, with a slide showing his photo and talk title: 'İkinci Bir Şans: Organ Rejenerasyonu ile Geleceği İnşa Etmek' \(A Second Chance: Building the Future with Organ Regeneration\).](https://ss.rapidrecap.app/screens/g5C9uEAVcwY/00-00-06.jpg)
![Screenshot at 01:30: A slide detailing the speaker's education and research areas, listing courses attended in Experimental Animals, Microsurgery, Laparoscopic, and Robotic Surgery.](https://ss.rapidrecap.app/screens/g5C9uEAVcwY/00-01-30.jpg)
![Screenshot at 02:57: A slide titled 'İnsanlığın Ölümsüzlük Arayışı – Tarihten Günümüze' showing ancient reliefs related to immortality myths \(Gilgamesh and Egyptian afterlife\).](https://ss.rapidrecap.app/screens/g5C9uEAVcwY/00-02-57.jpg)
![Screenshot at 05:54: A slide titled 'Yapay Karaciğer Teknolojisi' showing diagrams and images of different types of artificial liver systems, including bioreactors and non-niche systems.](https://ss.rapidrecap.app/screens/g5C9uEAVcwY/00-05-54.jpg)
![Screenshot at 14:32: A slide titled 'Sonuçlar sevindirdi...' displaying bar charts comparing inflammation markers \(IL-6\) and parenchymal necrosis between control groups and groups treated with amniotic fluid \(AF\) and MSCs.](https://ss.rapidrecap.app/screens/g5C9uEAVcwY/00-14-32.jpg)